TNF Polymorphisms and Cancer
نویسندگان
چکیده
منابع مشابه
TNF-α, TNF-β, IL-6, and IL-10 Polymorphisms in Patients with Lung Cancer
Apart from cigarette smoking, genetic factors seem to be of importance in the development of lung cancer. The present case-control study investigated frequencies of five inflammatory response gene polymorphisms (TNF-alpha-308, TNF-beta-Intron1-252, IL-6-174, IL-10-819 and IL-10-1082) in patients with lung cancer and controls. The study population consisted of 117 patients with lung cancer (77 p...
متن کاملTNF-α gene polymorphisms and expression
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in the pathogenesis of several diseases. Its encoding gene is located in the short arm of chromosome 6 in the major histocompatibility complex class III region. Most of the TNF-α gene polymorphisms are located in its promoter region and they are thought to affect the susceptibility and/or severity of differ...
متن کاملNo association of TNF-α-308G/A polymorphisms with head and neck cancer risk
BACKGROUND A number of studies had reported the association between tumor necrosis factor-alpha (TNF-α) gene polymorphisms and head and neck cancer (HNC) risk. However, the results remained controversial. Therefore, we performed a meta-analysis to derive a more precise evaluation of the association between TNF-α-308G/A polymorphism and overall HNC risk and evaluated influence of cancer types an...
متن کاملTNF-α gene promoter polymorphisms and risk of venous thromboembolism in gastrointestinal cancer patients undergoing chemotherapy.
BACKGROUND TNF-α has been proposed as a predictive factor for venous thromboembolism (VTE). Genetic polymorphisms could regulate TNF-α production. However, the relationship between TNFA gene variants and VTE is not clarified. This study aims to investigate the predictive role of five different TNFA gene promoter SNPs, or their haplotype combination(s), for a first VTE episode in gastrointestina...
متن کاملThe Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population
Objective Objective: TNF-α is an important cytokine in acute inflammatory response to infective factors. It seems that this response increases in patients with endometriosis due to presence of cytokines such as TNF-α which has been investigated in patients with endometriosis in different populations. This study aimed at examining four polymorphisms; TNF-α -238G/A, -308G/A, -857C/T and -863C/A a...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Cancer Prevention
سال: 2012
ISSN: 1513-7368
DOI: 10.7314/apjcp.2012.13.6.3007